MicroR-146 protects against rat ischemia-reperfusion injury by targeting NF-κB-mediated PI3K/AKT/mTOR signaling pathway

MicroR-146 (miR-146) plays crucial roles in attenuating nerve injury during cerebral ischemia-reperfusion (I/R) injury. The purpose of this study was to investigate the neuroprotective effect miR-146 against I/R Rat model established using 4-vessel occlusion and reperfusion. In study, expression significantly decreased neurons rat compared sham group. addition, miR-146+/+ inflammatory cytokines, oxidative stress, neuron cell apoptosis infarct size rats (p<0.05). Transfection reduced apoptosis, autophagy autophagy-related proteins LC-3, Beclin-1 increased p62 cells control Furthermore, overexpression indicated directly targeting NF-κB activating PI3K/AKT/mTOR cells. conclusion, these findings suggested that could protect by NF-κB-mediated signaling pathway, which offered a potential molecular for treatment